Dr. Marilyn Manco-Johnson

Biography

Dr. Marilyn Manco-Johnson received a BS from Penn State University, State College, PA and an MD from Thomas Jefferson University, Philadelphia, PA. She trained in pediatrics and pediatric Hematology/Oncology at the University of Colorado and Colorado Children’s Hospital.

Dr. Manco-Johnson’s career has been in clinical care as well as clinical and translational research of bleeding and clotting disorders. She oversees a large clinical and research program that cares for 2000 children and adults with coagulation disorders. The Colorado HTC integrates research into the comprehensive evaluation and management of bleeding and clotting disorders. Some examples of this research include development of novel global assays to evaluate coagulation; conduct of investigator-initiated and well as Pharma-sponsored trials for new therapies of hemophilia and thrombosis; pharmacokinetic and pathophysiological studies in rare clotting disorders; and animal models of human coagulation disorders.

Key Publications

Manco-Johnson MJ, Abshire TC, Shapiro AD, Riske B, Hacker MR, Kilcoyne R et al. Recombinant Factor VIII For the Prevention of Joint Disease in Children with Severe Hemophilia: Prophylaxis Compared With Episodic Treatment. NEJM 2007;357:535-44.
Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL, Rick ME, Sadler JE, Weinstein M, Yawn BP. von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). Haemophilia. 2008 Mar;14(2):171-232.
Kulkarni R, Soucie JM, Lusher J, Presley R, Shapiro A, Gill J, Manco-Johnson M, Koerper M, Mathew P, Abshire T, DiMichele , Hoots K, Janco R,Nugent D, Geraghty S, Evatt B; the Haemophilia Treatment Center Network Investigators. Sites of initial bleeding, mode of delivery and age of diagnosis in babies with haemophilia diagnosed before the age of 2 years: a report from The Centers for Disease Control and Prevention (CDC) Universal Data Collection (UDC) project. Haemophilia 2009; Nov;15(6):1281-90.
Simpson ML, Goldenberg NA, Jacobson LJ, Bombardier CG, Hathaway WE, Manco-Johnson MJ. Simultaneous thrombin and plasmin generation capacities in normal and abnormal states of coagulation and fibrinolysis in children and adults. Thromb Res 2011;127:317-23.
Goldenberg NA, Hathaway WE, Jacobson L, Manco-Johnson MJ. A new global assay of coagulation and fibrinolysis. Thromb Res 2005;116:345-56.
Manco-Johnson MJ. How I treat venous thrombosis in children. Blood 2006;107:1-9.
Goldenberg N, Knapp-Clevenger R, Manco-Johnson MJ. Elevated plasma factor VIII and D-dimer levels predict poor thrombotic outcomes in children. New Engl J Med 2004;351:1081-8.

Key Institutions

Children’s Hospital
Colorado, USA
University of Colorado
Department of Pediatrics
Aurora, CO, USA

Current Positions/Chairs

Director
Hemophilia and Thrombosis Center
Professor of Pediatrics
University of Colorado
Scientific PI
Surveillance of Complications of Bleeding and Clotting Disorders, a cooperative agreement between the US Hemophilia Treatment Center Network and the US Centers for Disease Control and Prevention.

Research Interests

Clinical research in the field of childhood bleeding disorders, particularly hemophilia, hemophilia inhibitors, afibrinogenemia, and neonatal hemostasis
Clinical research in the field of childhood clotting disorders, particularly severe protein C deficiency, antiphospholipid antibodies, thrombotic storm, and antithrombotic therapies.
Development and application of global assay of coagulation to bleeding and clotting disorders.

Research Activities

Clinical research in the field of childhood bleeding disorders, particularly hemophilia, hemophilia inhibitors, afibrinogenemia, and neonatal hemostasis
Clinical research in the field of childhood clotting disorders, particularly severe protein C deficiency, antiphospholipid antibodies, thrombotic storm, and antithrombotic therapies
Development and application of global assay of coagulation to bleeding and clotting disorders

Publications

March 25, 2022

The Hemophilia Joint Health Score version 2.1 Validation in Adult Patients Study: A multicenter international study.

Authors

St-Louis J, Abad A, Funk S, Tilak M, Classey S, Zourikian N, McLaughlin P, Lobet S, Hernandez G, Akins S, Wells AJ, Manco-Johnson M, John J, Austin S, Chowdary P, Hermans C, Nugent D, Bakeer N, Mangles S, Hilliard P, Blanchette VS, Feldman BM.

Citation

Res Pract Thromb Haemost. 2022 Mar 25;6(2):e12690. doi: 10.1002/rth2.12690. Erratum in: Res Pract Thromb Haemost. 2022 Apr 25;6(3):e12713. PMID: 35356667; PMCID: PMC8956786.

April 1, 2021

Musculoskeletal Ultrasound in Hemophilia: results and recommendations from a global survey and consensus meeting

Authors

Bakeer N, Dover S, Babyn P, Feldman BM, Drygalski A, Doria AS, Ignas DM, Abad A, Bailey C, Beggs I, Chang EY, Dunn A, Funk S, Sridhar Gibikote S,Goddard N , Hilliard P, Keshava S, Kruse-Jarres R, Li Y, Lobet S, Manco-Johnson M, Martinoli C, O’Donnell JS, Papakonstantinou O, Pergantou H, Poonnoose P, Querol F, Srivastava A, Steiner B, Strike K, Timmer M, Tyrrell PN, Logi Vidarsson L, Blanchette, VS

Citation

Res Pract Thromb Haemost . 2021 Jul 10;5(5):e12531. doi: 10.1002/rth2.12531. eCollection 2021 Jul.

October 15, 2020

Evaluating international Haemophilia Joint Health Score (HJHS) results combined with expert opinion: Options for a shorter HJHS.

Authors

Kuijlaars IAR, van der Net J, Feldman BM, Aspdahl M, Bladen M, de Boer W, CuestaBarriuso R, Matlary RED, Funk SM, Hilliard P, John JA, Kempton CL, de Kleijn P, MancoJohnson M, Petrini P, Poonnoose P, St-Louis J, Thomas S, Timmer MA, Trakymiene SS, van Vlimmeren L, Fischer K

Citation

Haemophilia. 2020 Oct 15. doi: 10.1111/hae.14180. Epub ahead of print. PMID:33058441.

August 11, 2020

Reference Ranges of HJHS Scores in Healthy Adult Males without Hemophilia

Authors

St-Louis J , Abad A , Akin S , Austin S , Chowdary P , Classey S , Funk S , Hernandez G ,Hilliard P, Manco-Johnson M , S. Mangles S , McLaughlin P , Nugent D , Shapiro A, Srivastava A , Tilak M , Wells A , Zourikian N , Blanchette V , Feldman BM.

Citation

Research Practice in Thrombosis and Haemostasis 2020; 4 (S1): 521, PB1032.

May 10, 2018

Elevated HJHS Scores in healthy adult males without hemophilia

Authors

Feldman B, Zourikian N, Funk S, Tilak M, Lobet S, Manco-Johnson M, Srivastava A, Hilliard P, Tiseo L and St-Louis J

Citation

Haemophilia 2018; 24 (S5): 176, W- FPMED01- 002

May 1, 2012

An MRI scale for assessment of hemophilic arthropathy from the International Prophylaxis Study Group.

Authors

Lundin B, Manco-Johnson ML, Ignas DM, Moineddin R, Blanchette VS, Dunn AL, Gibikote SV, Keshava SN, Ljung R, Manco-Johnson MJ, Miller SF, Rivard GE, Doria AS on behalf of the International Prophylaxis Study Group.

Citation

Haemophilia 2012 Nov; 18 (6):962-70

July 31, 2011

A Basic MRI Scale for Hemophilia Arthropathy from the International Prophylaxis Study Group (IPSG)

Authors

Lundin B, Manco-Johnson M, Miller SF, Moineddin R, Ignas DM, Ljung R, Dunn AL, Rivard GE, Babyn P, Keshava SN, Gibikote S, Blanchette VS, Doria AS.

Citation

Journal of Thrombosis and Haemostasis 2011; 9: 463

July 1, 2011

An MRI scale for assessment of hemophilic arthropathy from the International Prophylaxis Study Group

Authors

Lundin B, Manco-Johnson ML, Ignas DM, Moineddin R, Blanchette VS, Dunn AL, Gibikote SV, Keshava SN, Ljung R, Manco-Johnson MJ,Miller SF, Rivard GE, Doria AS on behalf of the International Prophylaxis Study Group.

Citation

XXIII International Society on Thrombosis and Haemostasis Congress (July 23-28, 2011 – Koyoto, Japan).

January 28, 2011

Validation of a new pediatric joint scoring system from the International Hemophilia Prophylaxis Study Group: Validity of the Hemophilia Joint Health Score (HJHS).

Authors

Feldman BM, Funk S, Bergstrom B-M, Zourikian N, Hilliard P, van der Net J, Engelbert RHH, Petrini P, van den Berg M , Manco-Johnson M, Rivard GE, Abad A, and Blanchette VS.

Citation

Arthritis Care & Research 2011 Feb; 63 (2):223-30.

July 1, 2008

The Haemophilia Joint Health Score (HJHS) international validation study.

Authors

Feldman B M, Funk S, Hilliard P, van der Net J, Zourikian N, Bergstrom B-M, Engelbert RHH, Abad A, Petrini P, Manco-Johnson M, and on behalf of the International Prophylaxis Study Group.

Citation

Haemophilia 2008, 14 (S2), 83 # 12 PO 85.

September 10, 2007

The economics of haemophilia prophylaxis: governmental and insurer perspectives. Proceedings of the Second International Prophylaxis Study Group (IPSG) Symposium.

Authors

Feldman BM, Aledort L, Bullinger M, Delaney FM, Doria AS, Funk S, Giangrande P, Lundin B, Manco-Johnson M, Miners A, Scriba PC, Srivastava A, Schramm W and Blanchette VS.

Citation

Haemophilia 2007 Nov; 13 (6): 745-749.

August 15, 2006

Hemophilia joint health score reliability study.

Authors

Hilliard P, Funk S, Zourikian N, Bergstrom B-M, Bradley CS, McLimont M, Manco-Johnson M, Petrini P, van den Berg M, and Feldman BM.

Citation

Haemophilia 2006 Sept; 12: 518 – 525.

August 15, 2006

Reliability study of the Hemophilia Joint Health Score.

Authors

Hilliard P, Funk S, Zourikian N, Bergstrom B-M, Bradley CS, McLimont M, Manco-Johnson M, Petrini P, van den Berg M, and Feldman BM.

Citation

Haemophilia 2004 Oct; 10 (S3): 79 # 16 S 03.

January 21, 2005

Proceedings of the International Haemophilia Prophylaxis Study Group Meeting November 2003, Montreal, PQ, Canada.

Authors

Feldman BM, Babyn P, Doria AS, Heijnen L, Jacobson J, Kilcoyne R, Lundin B, Manco-Johnson M, McLimont M, Petrini P, Pettersson H, and Blanchette VS on behalf of the IPSG.

Citation

Haemophilia 2005 Jan; 11: 58 – 63.

October 8, 2004

Physical therapy and imaging outcome measures in a haemophilia population treated with factor prophylaxis: current status and future directions.

Authors

Manco-Johnson MJ, Pettersson H, Petrini P, Babyn PS, Bergstrom B-M, Bradley CS , Doria AS, Feldman BM, Funk S, Hilliard P, Kilcoyne R, Lundin B, Nuss R, Rivard G, Schoenmakers MA, van den berg M, Wiedel J, Zourikian N, and Blanchette VS.

Citation

Haemophilia 2004 Oct; 10 (S4):88 – 93.