Clinical Prophylaxis

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Publications

May 20, 2021

Terminal half-life of FVIII and FIX according to age, blood group and concentrate type: data from the WAPPS database

Authors
Versloot O, Iserman E, Chelle P, Germini F, Edginton AN, Schutgens REG, Iorio A, Fischer K; Pharmacokinetic (PK) Expert Working Group of the International Prophylaxis Study Group (IPSG).
Citation
J Thromb Haemost. 2021 May 20. doi: 10.1111/jth.15395. Epub ahead of print. PMID: 34013558.
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April 1, 2021

Musculoskeletal Ultrasound in Hemophilia: results and recommendations from a global survey and consensus meeting

Authors
Bakeer N, Dover S, Babyn P, Feldman BM, Drygalski A, Doria AS, Ignas DM, Abad A, Bailey C, Beggs I, Chang EY, Dunn A, Funk S, Sridhar Gibikote S,Goddard N , Hilliard P, Keshava S, Kruse-Jarres R, Li Y, Lobet S, Manco-Johnson M, Martinoli C, O’Donnell JS, Papakonstantinou O, Pergantou H, Poonnoose P, Querol F, Srivastava A, Steiner B, Strike K, Timmer M, Tyrrell PN, Logi Vidarsson L, Blanchette, VS
Citation
Research and Practice in Thrombosis and Haemostasis. Accepted April 2021
December 5, 2020

Not All Patients Benefit from Switching to Ehl: Results from the Wapps Database

The 62nd ASH Annual Meeting and Exposition (Dec 5-8, 2020)
Authors
Versloot O, Iserman E, Chelle P, Germini,F, Mathew T, Iorio A, and Fischer K
Citation
December 5, 2020

Terminal Half-Life of Factor VIII/IX According to Age and Blood Group Based on 8550 Assessments.

The 62nd ASH Annual Meeting and Exposition (Dec 5-8, 2020)
Authors
Versloot O, Iserman E, Chelle P, Germini,F, Mathew T, Iorio A, and Fischer K.
Citation
November 5, 2020

Not All Patients Benefit from Switching to Ehl: Results from the Wapps Database

Authors
Versloot O, Iserman E, Chelle P, Germini,F, Mathew T, Iorio A, and Fischer K
Citation
Blood 2020; 136 (S1): 21-22.
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November 5, 2020

Terminal Half-Life of Factor VIII/IX According to Age and Blood Group Based on 8550 Assessments

Authors
Versloot O, Iserman E, Chelle P, Germini,F, Mathew T, Iorio A, and Fischer K
Citation
Blood 2020; 136 (S1): 22-23
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October 15, 2020

Evaluating international Haemophilia Joint Health Score (HJHS) results combined with expert opinion: Options for a shorter HJHS.

Authors
Kuijlaars IAR, van der Net J, Feldman BM, Aspdahl M, Bladen M, de Boer W, CuestaBarriuso R, Matlary RED, Funk SM, Hilliard P, John JA, Kempton CL, de Kleijn P, MancoJohnson M, Petrini P, Poonnoose P, St-Louis J, Thomas S, Timmer MA, Trakymiene SS, van Vlimmeren L, Fischer K
Citation
Haemophilia. 2020 Oct 15. doi: 10.1111/hae.14180. Epub ahead of print. PMID: 33058441.
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August 11, 2020

Reference Ranges of HJHS Scores in Healthy Adult Males without Hemophilia

Authors
St-Louis J , Abad A , Akin S , Austin S , Chowdary P , Classey S , Funk S , Hernandez G , Hilliard P, Manco-Johnson M , S. Mangles S , McLaughlin P , Nugent D , Shapiro A, Srivastava A , Tilak M , Wells A , Zourikian N , Blanchette V , Feldman BM.
Citation
Research Practice in Thrombosis and Haemostasis 2020; 4 (S1): 521, PB1032.
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July 12, 2020

Reference Ranges of HJHS Scores in Healthy Adult Males without Hemophilia

The 2020 Virtual Congress of the International Society on Thrombosis and Haemostasis (July 12 - 14, 2020)
Authors
St-Louis J , Abad A , Akin S , Austin S , Chowdary P , Classey S , Funk S , Hernandez G , Hilliard P, Manco-Johnson M , S. Mangles S , McLaughlin P , Nugent D , Shapiro A, Srivastava A , Tilak M , Wells A , Zourikian N , Blanchette V , Feldman BM
Citation
May 22, 2020

Use of ultrasound for assessment of musculoskeletal disease in persons with haemophilia: Results of an international prophylaxis study group global survey

Authors
Ignas DM, Doria AS, von Drygalski A, Blanchette VS, Chang EY, Dover S, Fischer K, Gibikote S, Keshava S, Querol F, Abad A, and Babyn P on behalf of the Ultrasound Taskforce of the Imaging Expert Working Group of the International Prophylaxis Study Group (IPSG)
Citation
Haemophilia 2020: 26 (4): 685 - 693
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May 20, 2018

Elevated HJHS scores in healthy adult males without hemophilia

The XXXI World Federation of Hemophilia Congress (May 20 -24, 2018 – Glasgow, Scotland)
Authors
St-Louis J, Zourikian N, Funk S, Tilak M, Lobet S, Manco-Johnson M, Srivastava A, Hilliard P, Tiseo L, Abad A, Wells A, Mangles S, Blanchette V and Feldman B.
Citation
May 20, 2018

Use of ultrasound for assessment of musculoskeletal disease in persons with hemophilia: Results of an International Prophylaxis Study Group (IPSG) survey

The XXXI World Federation of Hemophilia Congress (May 20 - 24, 2018 – Glasgow, Scotland)
Authors
Doria AS, von Drygalski A, Blanchette VS, Chang EY, Dover S, Fischer K, Sridhar G, Shyamkumar K, Querol F, Babyn P
Citation
May 10, 2018

Elevated HJHS Scores in healthy adult males without hemophilia

Authors
Feldman B, Zourikian N, Funk S, Tilak M, Lobet S, Manco-Johnson M, Srivastava A, Hilliard P, Tiseo L and St-Louis J
Citation
Haemophilia 2018; 24 (S5): 176, W- FPMED01- 002
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May 10, 2018

Use of ultrasound for assessment of musculoskeletal disease in persons with hemophilia: Results of an International Prophylaxis Study Group (IPSG) survey.

Authors
Doria AS, von Drygalski A, Blanchette VS, Chang EY, Dover S, Fischer K, Sridhar G, Shyamkumar K, Querol F, Babyn P.
Citation
Haemophilia 2018; 24 (S5): 391, W- P- 085
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April 24, 2017

An International Prophylaxis Study Group (IPSG) survey of prophylaxis in inhibitor positive children/adults with severe haemophilia

Authors
Carcao MD, Avila L, Leissinger C, Blanchette VS, Aledort L; Factor Utilization Expert Working Group on behalf of the International Prophylaxis Study Group (IPSG) and participating Survey Investigators.
Citation
Haemophilia 2017; 23 (5) : e444 - e447
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April 21, 2017

An International Prophylaxis Study Group (IPSG) survey of prophylaxis in adults with severe haemophilia

Authors
Carcao M, Avila L, Leissinger C, Blanchette VS, and Aledort LM on behalf of the Factor Utilization Expert Working Group of the International Prophylaxis Study Group (IPSG) and participating Survey Investigators
Citation
Haemophilia 2017; 23 (5): e447 - e450
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December 3, 2015

Hemophilia prophylaxis no longer just for children without inhibitors – increasing use of prophylaxis in other groups (children with inhibitors and adults with and without inhibitors)

Authors
Carcao M, Avila L, Blanchette V, Santagostino E, Escuriola-Ettingshausen C, Leissinger C, Lambert T, Aledort L on behalf of the International Prophylaxis Study Group (IPSG) and Survey Investigators.
Citation
Blood 2015; 126: 3535
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June 20, 2015

Prophylaxis in adult patients with severe hemophilia A or B without inhibitors.

The XXV Congress of the International Society on Thrombosis and Haemostasis (June 20–25, 2015 – Toronto, Canada)
Authors
Carcao, M on behalf of Factor Utilization Expert Working Group of the International Prophylaxis Study Group (IPSG) and other Survey Investigators.
Citation
June 20, 2015

Prophylaxis practices in children and adults with inhibitors

The XXV Congress of the International Society on Thrombosis and Haemostasis (June 20 - 25, 2015 – Toronto, Canada)
Authors
Carcao M, Avila M, Aledort L, Leissinger C on behalf of Factor Utilization Expert Working Group of the International Prophylaxis Study Group (IPSG) and other Survey Investigators
Citation
May 11, 2014

Global utilization of the International Prophylaxis Study Group (IPSG) physical therapy education web-site module

The XXX World Federation of Hemophillia Congress (May 11 -15, 2014 – Melbourne, Australia)
Authors
Hilliard P, Abad A, Feldman B M, Funk S, Manco-Johnson M, Petrini P, van der Net J, Zourikian N, and Blanchette VS on behalf of the International Prophylaxis Study Group
Citation
July 1, 2012

Tertiary prophylaxis in adults: What is the rationale?

Authors
Gringeri A, Lambert T, Street A, and Aledort L. on behalf of the Adolescent/Adult Prophylaxis Study Group of the International Prophylaxis Study Group.
Citation
Haemophilia 2012 Sept; 18 (5): 722-728
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May 1, 2012

An MRI scale for assessment of hemophilic arthropathy from the International Prophylaxis Study Group.

Authors
Lundin B, Manco-Johnson ML, Ignas DM, Moineddin R, Blanchette VS, Dunn AL, Gibikote SV, Keshava SN, Ljung R, Manco-Johnson MJ, Miller SF, Rivard GE, Doria AS on behalf of the International Prophylaxis Study Group.
Citation
Haemophilia 2012 Nov; 18 (6):962-70
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April 17, 2012

Hemophilia Prophylaxis: How can we justify the costs?

Authors
Feldman BM, Berger K, Bohn R, Carcao M, Fischer K, Gringeri A, Hoots K, Mantovani L, Willan A, and Schramm W.
Citation
Haemophilia 2012 Sept; 18 (5): 680-684.
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February 22, 2012

Why should we Care about Quality of Life in Hemophilia?

Authors
Aledort L, Bullinger M, von Mackensen S, Wasserman J, and Young NL. on behalf of the Health Related Quality of Life Expert Working Group of the International Prophylaxis Study Group.
Citation
Haemophilia 2012; May 18 (3) : e154 – e157.
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July 31, 2011

A Basic MRI Scale for Hemophilia Arthropathy from the International Prophylaxis Study Group (IPSG)

Authors
Lundin B, Manco-Johnson M, Miller SF, Moineddin R, Ignas DM, Ljung R, Dunn AL, Rivard GE, Babyn P, Keshava SN, Gibikote S, Blanchette VS, Doria AS.
Citation
Journal of Thrombosis and Haemostasis 2011; 9: 463
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July 23, 2011

An MRI scale for Assessment of Hemophilic Arthropathy from the International Prophylaxis Study Group

The XXIII International Society on Thrombosis & Haemostasis Congress (July 23-28, 2011 – Kyoto, Japan).
Authors
Lundin B, Manco-Johnson ML, Ignas D, Moineddin R , Babyn P, Blanchette VS, Dunn A , Gibikote SV, Keshava SN, Ljung R, Manco-Johnson MJ ,Miller SF, Rivard GE, Doria AS on behalf of the International Prophylaxis Study Group.
Citation
Award: Red ribbon award for the top ranked 20% of poster presentations.
July 1, 2011

An MRI scale for assessment of hemophilic arthropathy from the International Prophylaxis Study Group

Haemophilia 2012 Nov; 18 (6):962-70
Authors
Lundin B, Manco-Johnson ML, Ignas DM, Moineddin R, Blanchette VS, Dunn AL, Gibikote SV, Keshava SN, Ljung R, Manco-Johnson MJ,Miller SF, Rivard GE, Doria AS on behalf of the International Prophylaxis Study Group.
Citation
Accepted to the XXIII International Society on Thrombosis and Haemostasis Congress (July 23-28, 2011 – Koyoto, Japan).
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January 28, 2011

Validation of a new pediatric joint scoring system from the International Hemophilia Prophylaxis Study Group: Validity of the Hemophilia Joint Health Score (HJHS).

Authors
Feldman BM, Funk S, Bergstrom B-M, Zourikian N, Hilliard P, van der Net J, Engelbert RHH, Petrini P, van den Berg M , Manco-Johnson M, Rivard GE, Abad A, and Blanchette VS.
Citation
Arthritis Care & Research 2011 Feb; 63 (2):223-30.
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October 29, 2009

Use of the Hemophilia Joint Health Score

Physical Therapy Pre-Conference Symposium National Hemophilia Foundation 2009 Annual Meeting (October 29-31, 2009 - San Francisco, CA, USA).
Authors
Funk, S.
Citation
July 1, 2008

The Haemophilia Joint Health Score (HJHS) international validation study.

Authors
Feldman B M, Funk S, Hilliard P, van der Net J, Zourikian N, Bergstrom B-M, Engelbert RHH, Abad A, Petrini P, Manco-Johnson M, and on behalf of the International Prophylaxis Study Group.
Citation
Haemophilia 2008, 14 (S2), 83 # 12 PO 85.
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July 1, 2008

A review of health economic studies in hemophilia prophylaxis: a collaboration of the economics expert working group of the International Prophylaxis Study Group (IPSG).

Authors
Carcao M, Fischer K, Steen-Carlsson K, Schramm W, Feldman B, and Berger K.
Citation
Haemophilia 2008, 14 (S2), 133 # 24 PO 17.
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June 1, 2008

A review of health economic studies in hemophilia prophylaxis: a collaboration of the economics expert working group of the International Prophylaxis Study Group (IPSG)

The XXVIII World Federation of Hemophillia Congress (June 1-5, 2008 – Istanbul, Turkey).
Authors
Carcao M, Fischer K, Steen-Carlsson K, Schramm W, Feldman B, and Berger K.
Citation
June 1, 2008

The Haemophilia Joint Health Score (HJHS) international validation study

The XXVIII World Federation of Hemophillia Congress (June 1-5, 2008 – Istanbul, Turkey).
Authors
Feldman B M, Funk S, Hilliard P, van der Net J, Zourikian N, Bergstrom B-M, Engelbert RHH, Abad A, Petrini P, Manco-Johnson M, and on behalf of the International Prophylaxis Study Group.
Citation
June 1, 2008

PT HJHS Pre-Congress Workshop

The XXVII International Congress of the World Federation of Hemophillia (June 1-5, 2008 – Istanbul, Turkey)
Authors
Hilliard, P, Funk S, Zourikian N, Bergstrom B-M, van der Net JJ, and Feldman BM
Citation
June 1, 2008

Musculoskeletal measurement tools from the International Prophylaxis Study Group (IPSG)

The XXVIII World Federation of Hemophilia Congress (June 1-5, 2008 – Istanbul, Turkey) Invited symposium as part of the scientific program of the WFH Congress (Chair: Dr. Victor Blanchette). Dr. Victor Blanchette, Overview of the International Prophylaxis Study Group, Ms. Sharon Funk and Dr. Brian Feldman, Hemophilia Joint Health Score. Dr. Andrea Doria and Dr. Bjorn Lundin, Role of MRI for detection of early arthropathy: A proposed new International MRI Score.
Authors
Feldman BM, Funk S, Lundin B, Doria AS, Blanchette V.
Citation
May 16, 2008

Musculoskeletal measurement tools from the International Prophylaxis Study Group (IPSG).

Authors
Feldman BM, Funk S, Lundin B, Doria AS, Ljung R, and Blanchette V.
Citation
Haemophilia 2008, 14 (Suppl. 3), 162-169.
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April 23, 2008

Introduction of Hemophilia Joint Health Score

Second Buzias Hemophilia Rehab Meeting (April 23-24, 2008 - Buzias, Romania)
Authors
van der Net J
Citation
December 30, 2007

Reliability and construct validity of the compatible MRI scoring system for evaluation of elbows in haemophilic children.

Authors
Doria AS, Lundin B, Miller S, Kilcoyne R (In Memoriam), Dunn A, Thomas S, Rivard G, Moineddin R, Babyn PS, and the Expert Imaging Working Group of the International Prophylaxis Study Group.
Citation
Haemophilia 2008 Mar; 14 (2): 303 - 314.
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November 13, 2007

Recommendations for reporting economic evaluations of haemophilia prophylaxis: a nominal groups consensus statement on behalf of the Economics Expert Working Group of the International Prophylaxis Study Group.

Authors
Nicholson A, Berger K, Bohn R, Carcao M, Fischer K, Gringeri A, Mantovani L, Hoots K,, Schramm W, van Hout BA, Willan AR, and Feldman BM.
Citation
Haemophilia 2008 Jan; 14 (1):127 -132.
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September 10, 2007

The economics of haemophilia prophylaxis: governmental and insurer perspectives. Proceedings of the Second International Prophylaxis Study Group (IPSG) Symposium.

Authors
Feldman BM, Aledort L, Bullinger M, Delaney FM, Doria AS, Funk S, Giangrande P, Lundin B, Manco-Johnson M, Miners A, Scriba PC, Srivastava A, Schramm W and Blanchette VS.
Citation
Haemophilia 2007 Nov; 13 (6): 745-749.
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August 15, 2006

Reliability and construct validity of the compatible MRI scoring system for evaluation of haemophilic knees and ankles of haemophilic children. Expert MRI Working Group of the International Prophylaxis Study Group.

Authors
Doria AS, Babyn PS, Lundin B, Kilcoyne RF, Miller S, Rivard GE, Moineddin R, and Pettersson H.
Citation
Haemophilia 2006 Sept; 12: 503 – 513.
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August 15, 2006

Hemophilia joint health score reliability study.

Authors
Hilliard P, Funk S, Zourikian N, Bergstrom B-M, Bradley CS, McLimont M, Manco-Johnson M, Petrini P, van den Berg M, and Feldman BM.
Citation
Haemophilia 2006 Sept; 12: 518 – 525.
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August 15, 2006

Reliability study of the Hemophilia Joint Health Score.

Authors
Hilliard P, Funk S, Zourikian N, Bergstrom B-M, Bradley CS, McLimont M, Manco-Johnson M, Petrini P, van den Berg M, and Feldman BM.
Citation
Haemophilia 2004 Oct; 10 (S3): 79 # 16 S 03.
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June 10, 2006

Hemophilia Joint Health Score instructional video and manual.

Authors
Hilliard P, Abad A, Bradley CS, Funk S, Zourikian N, and Bergstrom B-M.
Citation
Haemophilia 2006 May; 12 (S2): # 18 FP 532
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May 21, 2006

Hemophilia Joint Health Score instructional video and manual

The XXVII World Federation of Hemophillia Congress (May 21-25, 2006 - Vancouver, Canada).
Authors
Hilliard P, Abad A, Bradley CS, Funk S, Zourikian N, and Bergstrom B-M.
Citation
May 21, 2006

MRI Scoring Systems in hemophilic arthropathy

The XXVII World Federation of Hemophillia Congress (May 21-25, 2006 - Vancouver, Canada).
Authors
Lundin B, Doria A, Kilcoyne R, Babyn P, Miller S, Nuss R, Rivard G, Pettersson H, and Blanchette V.
Citation
May 21, 2006

Discriminant validity and reliability of the Compatible MRI Scoring System for assessment of hemophilic arthropathy in children

The XXVII World Federation of Hemophillia Congress (May 21-25, 2006 - Vancouver, Canada).
Authors
Doria AS, Lundin B, Kilcoyne RF, Babyn PS, Miller SW, Nuss R, Rivard G, Pettersson HT, and Blanchette V.
Citation
May 21, 2006

Recent developments in clinimetric instruments

The XXVII World Federation of Hemophillia Congress (May 21-25, 2006 - Vancouver, Canada) Invited symposium as part of the scientific program of the WFH Congress (Chair: Karen Beeton). Funk S & Hilliard P – International Joint Health Score: Clinical Scoring System
Authors
Funk S, Hilliard P, Doria AS, Lundin B on behalf of the IPSG
Citation
May 10, 2006

MRI scoring systems in hemophilic arthropathy.

Authors
Lundin B, Doria A, Kilcoyne R, Babyn P, Miller S, Nuss R, Rivard G, Pettersson H, and Blanchette V.
Citation
Haemophilia 2006 May; 12 (S2): # 22 S 685
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May 10, 2006

Discriminant validity and reliability of the Compatible MRI Scoring System for assessment of hemophilic arthropathy in children.

Authors
Doria A, Lundin B, Kilcoyne RF, Babyn PS, Miller SW, Pettersson HT, and Blanchette V.
Citation
Haemophilia 2006 May; 12 (S2): # 22 S 686
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March 4, 2006

Are randomized clinical trials the only truth? Not always

Authors
Aledort L, Ljung R, and Blanchette V on behalf of the International Prophylaxis Study Group (IPSG)
Citation
Journal of Thrombosis and Haemostasis 2006 Mar; 4 (3): 503 - 504.
September 9, 2005

Radiological Scoring in Hemophilic Arthropathy

The IX World Federation of Hemophilia Musculoskeletal Congress (September 9-11, 2005 - Istanbul, Turkey).
Authors
Lundin B and Blanchette V on behalf of the IPSG MRI Working Group
Citation
May 5, 2005

Reliability of progressive and additive MRI scoring systems for evaluation of haemophilic arthropathy in children: Expert MRI Working Group of the International Prophylaxis Study Group.

Authors
Doria AS, Lundin B, Kilcoyne RF, Babyn PS, Miller S, Nuss R, Rivard G, Stephens D, and Pettersson H.
Citation
Haemophilia 2005 May; 11: 245 – 253
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March 15, 2005

Compatible scales for progressive and additive MRI assessments of haemophilic arthropathy.

Authors
Lundin B, Babyn P, Doria AS, Kilcoyne R, Ljung R, Miller S, Nuss R, Rivard GE, and Pettersson H on behalf of the International Prophylaxis Study Group.
Citation
Haemophilia 2005 Mar; 11: 109 – 115.
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March 15, 2005

Compatible scales for progressive and additive magnetic resonance imaging assessments of haemophilic arthropathy.

Authors
Lundin B, Nuss R, Kilcoyne R, Doria A, Pettersson H, and Ljung R.
Citation
Haemophilia 2004 Oct; 10 (S3): 79 # 16 S 02.
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January 21, 2005

Proceedings of the International Haemophilia Prophylaxis Study Group Meeting November 2003, Montreal, PQ, Canada.

Authors
Feldman BM, Babyn P, Doria AS, Heijnen L, Jacobson J, Kilcoyne R, Lundin B, Manco-Johnson M, McLimont M, Petrini P, Pettersson H, and Blanchette VS on behalf of the IPSG.
Citation
Haemophilia 2005 Jan; 11: 58 – 63.
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October 17, 2004

Compatible scales for progressive and additive magnetic resonance imaging assessments of haemophilic arthropathy

The XXVI World Federation of Hemophillia Congress (October 17-21, 2004 - Bangkok, Thailand).
Authors
Lundin B, Nuss R, Kilcoyne R, Doria A, Pettersson H, and Ljung R
Citation
October 17, 2004

Physical therapy and imaging outcome measures in a haemophilia population treated with factor prophylaxis: current status and future directions

The XXVI World Federation of Hemophillia Congress (October 17-21, 2004 - Bangkok, Thailand). Invited symposium as part of the scientific program of the WFH Congress (Chairs: Dr. Victor. Blanchette and Dr. Marilyn Manco-Johnson). Dr. Victor Blanchette, Opening remarks. Dr. Bjorn Lundin, X-ray.MRI Scoring Systems: Overview. Dr. Andrea Doria, Compatible Scales for progressive and additive MRI of hemophilic arthropathy. Dr. Pia Petrini, Physical Therapy Scale Overview. Dr. Brian Feldman, Reliability of the Hemophilia Joint Health Score (HJHS).
Authors
Doria AS, Feldman BM, Lundin B, and Blanchette VS on behalf of the IPSG
Citation
October 17, 2004

Reliability study of the Hemophilia Joint Health Score

The XXVI World Federation of Hemophillia Congress (October 17-21, 2004 - Bangkok, Thailand).
Authors
Hilliard P, Funk S, Zourikian N, Bergstrom B-M, Bradley CS, McLimont M, Manco-Johnson M, Petrini P, van den Berg M, and Feldman BM.
Citation
October 8, 2004

Physical therapy and imaging outcome measures in a haemophilia population treated with factor prophylaxis: current status and future directions.

Authors
Manco-Johnson MJ, Pettersson H, Petrini P, Babyn PS, Bergstrom B-M, Bradley CS , Doria AS, Feldman BM, Funk S, Hilliard P, Kilcoyne R, Lundin B, Nuss R, Rivard G, Schoenmakers MA, van den berg M, Wiedel J, Zourikian N, and Blanchette VS.
Citation
Haemophilia 2004 Oct; 10 (S4):88 – 93.
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