Pharmacokinetics

Dr. Guy Young

Guy Young, MD, received his medical degree from the State University of New York at Stony Brook School of Medicine in Stony Brook, New York. He completed a residency in pediatrics at Schneider Children’s Hospital at Long Island Jewish Medical Center, Albert Einstein College of Medicine in New York, and a fellowship in pediatric hematology/oncology at Children’s National Medical Center, George Washington University School of Medicine in Washington, D.C.

Dr. Young is the Director of the Hemostasis and Thrombosis Center at Children’s Hospital Los Angeles and an Associate Professor of Pediatrics at the University of Southern California’s Keck School of Medicine.

His current research activities encompass clinical trials in hemophilia, the use of novel anticoagulants in children, and the development of the global hemostasis assays to monitor the effects of medications used to treat bleeding in hemophilia.

Dr. Young has published many journal articles, abstracts, and textbook chapters and has delivered lectures, workshops, and presentations at national and international meetings. He is a past Board member and past chair of the program committee for the American Society of Pediatric Hematology/Oncology, and also a past chair of the program committee for the Hemophilia and Thrombosis Research Society. He is the former chair of the Scientific and Standardization Committee on Factor VIII, Factor IX, and Rare Bleeding Disorders of the International Society on Thrombosis and Haemostasis and also served on the Scientific Subcommittee on Hemostasis for the American Society of Hematology. He has been awarded the National Hemophilia Foundation Physician of the Year Award in 2013.

Key Publications

Young G, Mahlangu J, Kulkarni, R, Nolan B, Liesner R, Pasi J, Barnes C, Neelankantan S, Gambino G, Cristiano LM, Pierce GF, Allen G. Recombinant factor VIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A. J Thromb Hemost 2015; 13:967-977.

Peyvandi F, Mannucci PM, Garagiola I, El-Beshlawy A, Elalfy M, Ramanan V, Eshghi P, Hanagavadi S, Varadarajan R, Karimi M, Manglani MV, Ross C, Young G et al. A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A. N  Engl J Med 374:2054-64.

Peyvandi F, Garagiola I, Young G. The past and future of haemophilia: diagnosis, treatments, and its complications. Lancet. 2016 Feb 17. pii: S0140-6736(15)01123-X. doi: 10.1016/S0140-6736(15)01123-X. [Epub ahead of print]

Young G, Sorensen B, Dargaud Y, Negrier C, Brummel-Ziedins K, Key NS. Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state-of-the-art and future perspectives. Blood, 2013; 121:1944-1950. [This article was cited as one of the noteworthy articles of 2013 by the American Society of Hematology]

Current Positions/Chairs:

  • Director, Children’s Hospital Los Angeles Hemostasis and Thrombosis Center
  • Professor of Pediatrics, University of Southern California Keck School of Medicine
  • Chair- FVIII, FIX and Rare Bleeding Disorders SSC of ISTH
  • Scientific Subcommittee on Hemostasis, American Society of Hematology

Key Institutions

  • Children’s Hospital Los Angeles
    Center for Childhood Cancer and Blood Disorders and The Saban Research Institute
  • The University of Southern California Keck School of Medicine
    Department of Pediatrics, Division of Pediatric Hematology/Oncology

Research Interests

  • Global hemostasis assays
  • Inhibitor treatment
  • Hemophilia clinical trials of new agents
  • New Thrombotic agent clinical trials in children

Achievements

  • National Hemophilia Foundation Physician of the Year 2013
  • World Federation of Hemophilia Twins of the Year 2014
  • Chair, FVIII, FIX, Rare Bleeding Disorders SSC, 2015-present