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Dr. Marilyn J. Manco-Johnson
MD

Dr. Marilyn Manco-Johnson received a BS from Penn State University, State College, PA and an MD from Thomas Jefferson University, Philadelphia, PA.  She trained in pediatrics and pediatric Hematology/Oncology  at the University of Colorado and Colorado Children’s Hospital.

Dr. Manco-Johnson’s career has been in clinical care as well as clinical and translational research of bleeding and clotting disorders.   She oversees a large clinical and research program that cares for 2000 children and adults with coagulation disorders. The Colorado HTC integrates research into the comprehensive evaluation and management of bleeding and clotting disorders.  Some examples of this research include development of novel global assays to evaluate coagulation; conduct of investigator-initiated and well as Pharma-sponsored trials for new therapies of hemophilia and thrombosis; pharmacokinetic and pathophysiological studies in rare clotting disorders; and animal models of human coagulation disorders.

Key Publications
  1. 1. Manco-Johnson MJ, Abshire TC, Shapiro AD, Riske B, Hacker MR, Kilcoyne R et al. Recombinant Factor VIII For the Prevention of Joint Disease in Children with Severe Hemophilia: Prophylaxis Compared With Episodic Treatment. NEJM 2007;357:535-44.
  2. Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL, Rick ME, Sadler JE, Weinstein M, Yawn BP. von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). Haemophilia. 2008 Mar;14(2):171-232.
  3. Kulkarni R, Soucie JM, Lusher J, Presley R, Shapiro A, Gill J, Manco-Johnson M, Koerper M, Mathew P, Abshire T, DiMichele , Hoots K, Janco R,Nugent D, Geraghty S, Evatt B; the Haemophilia Treatment Center Network Investigators. Sites of initial bleeding, mode of delivery and age of diagnosis in babies with haemophilia diagnosed before the age of 2 years: a report from The Centers for Disease Control and Prevention (CDC) Universal Data Collection (UDC) project. Haemophilia 2009; Nov;15(6):1281-90.
  4. Simpson ML, Goldenberg NA, Jacobson LJ, Bombardier CG, Hathaway WE, Manco-Johnson MJ. Simultaneous thrombin and plasmin generation capacities in normal and abnormal states of coagulation and fibrinolysis in children and adults. Thromb Res 2011;127:317-23.
  5. Goldenberg NA, Hathaway WE, Jacobson L, Manco-Johnson MJ. A new global assay of coagulation and fibrinolysis. Thromb Res 2005;116:345-56.
  6. Manco-Johnson MJ. How I treat venous thrombosis in children. Blood 2006;107:1-9.
  7. Goldenberg N, Knapp-Clevenger R, Manco-Johnson MJ. Elevated plasma factor VIII and D-dimer levels predict poor thrombotic outcomes in children. New Engl J Med 2004;351:1081-8.

Current Positions/Chairs:

  • Director
    Hemophilia and Thrombosis Center
  • Professor of Pediatrics
    University of Colorado
  • Scientific PI
    Surveillance of Complications of Bleeding and Clotting Disorders, a cooperative agreement between the US Hemophilia Treatment Center Network and the US Centers for Disease Control and Prevention.

Key Institutions

  • Children’s Hospital
    Colorado, USA
  • University of Colorado
    Department of Pediatrics
    Aurora, CO, USA

Research Activities

  • Clinical research in the field of childhood bleeding disorders, particularly hemophilia, hemophilia inhibitors, afibrinogenemia, and neonatal hemostasis
  • Clinical research in the field of childhood clotting disorders, particularly severe protein C deficiency, antiphospholipid antibodies, thrombotic storm, and antithrombotic therapies
  • Development and application of global assay of coagulation to bleeding and clotting disorders

Research Interests

  • Clinical research in the field of childhood bleeding disorders, particularly hemophilia, hemophilia inhibitors, afibrinogenemia, and neonatal hemostasis
  • Clinical research in the field of childhood clotting disorders, particularly severe protein C deficiency, antiphospholipid antibodies, thrombotic storm, and antithrombotic therapies.
  • Development and application of global assay of coagulation to bleeding and clotting disorders.

Publications

April 1, 2021

Musculoskeletal Ultrasound in Hemophilia: results and recommendations from a global survey and consensus meeting

Authors
Bakeer N, Dover S, Babyn P, Feldman BM, Drygalski A, Doria AS, Ignas DM, Abad A, Bailey C, Beggs I, Chang EY, Dunn A, Funk S, Sridhar Gibikote S,Goddard N , Hilliard P, Keshava S, Kruse-Jarres R, Li Y, Lobet S, Manco-Johnson M, Martinoli C, O’Donnell JS, Papakonstantinou O, Pergantou H, Poonnoose P, Querol F, Srivastava A, Steiner B, Strike K, Timmer M, Tyrrell PN, Logi Vidarsson L, Blanchette, VS
Citation
Research and Practice in Thrombosis and Haemostasis. Accepted April 2021
October 15, 2020

Evaluating international Haemophilia Joint Health Score (HJHS) results combined with expert opinion: Options for a shorter HJHS.

Authors
Kuijlaars IAR, van der Net J, Feldman BM, Aspdahl M, Bladen M, de Boer W, CuestaBarriuso R, Matlary RED, Funk SM, Hilliard P, John JA, Kempton CL, de Kleijn P, MancoJohnson M, Petrini P, Poonnoose P, St-Louis J, Thomas S, Timmer MA, Trakymiene SS, van Vlimmeren L, Fischer K
Citation
Haemophilia. 2020 Oct 15. doi: 10.1111/hae.14180. Epub ahead of print. PMID: 33058441.
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August 11, 2020

Reference Ranges of HJHS Scores in Healthy Adult Males without Hemophilia

Authors
St-Louis J , Abad A , Akin S , Austin S , Chowdary P , Classey S , Funk S , Hernandez G , Hilliard P, Manco-Johnson M , S. Mangles S , McLaughlin P , Nugent D , Shapiro A, Srivastava A , Tilak M , Wells A , Zourikian N , Blanchette V , Feldman BM.
Citation
Research Practice in Thrombosis and Haemostasis 2020; 4 (S1): 521, PB1032.
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July 12, 2020

Reference Ranges of HJHS Scores in Healthy Adult Males without Hemophilia

The 2020 Virtual Congress of the International Society on Thrombosis and Haemostasis (July 12 - 14, 2020)
Authors
St-Louis J , Abad A , Akin S , Austin S , Chowdary P , Classey S , Funk S , Hernandez G , Hilliard P, Manco-Johnson M , S. Mangles S , McLaughlin P , Nugent D , Shapiro A, Srivastava A , Tilak M , Wells A , Zourikian N , Blanchette V , Feldman BM
Citation
May 20, 2018

Elevated HJHS scores in healthy adult males without hemophilia

The XXXI World Federation of Hemophilia Congress (May 20 -24, 2018 – Glasgow, Scotland)
Authors
St-Louis J, Zourikian N, Funk S, Tilak M, Lobet S, Manco-Johnson M, Srivastava A, Hilliard P, Tiseo L, Abad A, Wells A, Mangles S, Blanchette V and Feldman B.
Citation
May 10, 2018

Elevated HJHS Scores in healthy adult males without hemophilia

Authors
Feldman B, Zourikian N, Funk S, Tilak M, Lobet S, Manco-Johnson M, Srivastava A, Hilliard P, Tiseo L and St-Louis J
Citation
Haemophilia 2018; 24 (S5): 176, W- FPMED01- 002
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May 11, 2014

Global utilization of the International Prophylaxis Study Group (IPSG) physical therapy education web-site module

The XXX World Federation of Hemophillia Congress (May 11 -15, 2014 – Melbourne, Australia)
Authors
Hilliard P, Abad A, Feldman B M, Funk S, Manco-Johnson M, Petrini P, van der Net J, Zourikian N, and Blanchette VS on behalf of the International Prophylaxis Study Group
Citation
May 1, 2012

An MRI scale for assessment of hemophilic arthropathy from the International Prophylaxis Study Group.

Authors
Lundin B, Manco-Johnson ML, Ignas DM, Moineddin R, Blanchette VS, Dunn AL, Gibikote SV, Keshava SN, Ljung R, Manco-Johnson MJ, Miller SF, Rivard GE, Doria AS on behalf of the International Prophylaxis Study Group.
Citation
Haemophilia 2012 Nov; 18 (6):962-70
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July 31, 2011

A Basic MRI Scale for Hemophilia Arthropathy from the International Prophylaxis Study Group (IPSG)

Authors
Lundin B, Manco-Johnson M, Miller SF, Moineddin R, Ignas DM, Ljung R, Dunn AL, Rivard GE, Babyn P, Keshava SN, Gibikote S, Blanchette VS, Doria AS.
Citation
Journal of Thrombosis and Haemostasis 2011; 9: 463
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July 23, 2011

An MRI scale for Assessment of Hemophilic Arthropathy from the International Prophylaxis Study Group

The XXIII International Society on Thrombosis & Haemostasis Congress (July 23-28, 2011 – Kyoto, Japan).
Authors
Lundin B, Manco-Johnson ML, Ignas D, Moineddin R , Babyn P, Blanchette VS, Dunn A , Gibikote SV, Keshava SN, Ljung R, Manco-Johnson MJ ,Miller SF, Rivard GE, Doria AS on behalf of the International Prophylaxis Study Group.
Citation
Award: Red ribbon award for the top ranked 20% of poster presentations.
July 1, 2011

An MRI scale for assessment of hemophilic arthropathy from the International Prophylaxis Study Group

Haemophilia 2012 Nov; 18 (6):962-70
Authors
Lundin B, Manco-Johnson ML, Ignas DM, Moineddin R, Blanchette VS, Dunn AL, Gibikote SV, Keshava SN, Ljung R, Manco-Johnson MJ,Miller SF, Rivard GE, Doria AS on behalf of the International Prophylaxis Study Group.
Citation
Accepted to the XXIII International Society on Thrombosis and Haemostasis Congress (July 23-28, 2011 – Koyoto, Japan).
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January 28, 2011

Validation of a new pediatric joint scoring system from the International Hemophilia Prophylaxis Study Group: Validity of the Hemophilia Joint Health Score (HJHS).

Authors
Feldman BM, Funk S, Bergstrom B-M, Zourikian N, Hilliard P, van der Net J, Engelbert RHH, Petrini P, van den Berg M , Manco-Johnson M, Rivard GE, Abad A, and Blanchette VS.
Citation
Arthritis Care & Research 2011 Feb; 63 (2):223-30.
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July 1, 2008

The Haemophilia Joint Health Score (HJHS) international validation study.

Authors
Feldman B M, Funk S, Hilliard P, van der Net J, Zourikian N, Bergstrom B-M, Engelbert RHH, Abad A, Petrini P, Manco-Johnson M, and on behalf of the International Prophylaxis Study Group.
Citation
Haemophilia 2008, 14 (S2), 83 # 12 PO 85.
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June 1, 2008

The Haemophilia Joint Health Score (HJHS) international validation study

The XXVIII World Federation of Hemophillia Congress (June 1-5, 2008 – Istanbul, Turkey).
Authors
Feldman B M, Funk S, Hilliard P, van der Net J, Zourikian N, Bergstrom B-M, Engelbert RHH, Abad A, Petrini P, Manco-Johnson M, and on behalf of the International Prophylaxis Study Group.
Citation
September 10, 2007

The economics of haemophilia prophylaxis: governmental and insurer perspectives. Proceedings of the Second International Prophylaxis Study Group (IPSG) Symposium.

Authors
Feldman BM, Aledort L, Bullinger M, Delaney FM, Doria AS, Funk S, Giangrande P, Lundin B, Manco-Johnson M, Miners A, Scriba PC, Srivastava A, Schramm W and Blanchette VS.
Citation
Haemophilia 2007 Nov; 13 (6): 745-749.
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August 15, 2006

Reliability study of the Hemophilia Joint Health Score.

Authors
Hilliard P, Funk S, Zourikian N, Bergstrom B-M, Bradley CS, McLimont M, Manco-Johnson M, Petrini P, van den Berg M, and Feldman BM.
Citation
Haemophilia 2004 Oct; 10 (S3): 79 # 16 S 03.
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August 15, 2006

Hemophilia joint health score reliability study.

Authors
Hilliard P, Funk S, Zourikian N, Bergstrom B-M, Bradley CS, McLimont M, Manco-Johnson M, Petrini P, van den Berg M, and Feldman BM.
Citation
Haemophilia 2006 Sept; 12: 518 – 525.
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January 21, 2005

Proceedings of the International Haemophilia Prophylaxis Study Group Meeting November 2003, Montreal, PQ, Canada.

Authors
Feldman BM, Babyn P, Doria AS, Heijnen L, Jacobson J, Kilcoyne R, Lundin B, Manco-Johnson M, McLimont M, Petrini P, Pettersson H, and Blanchette VS on behalf of the IPSG.
Citation
Haemophilia 2005 Jan; 11: 58 – 63.
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October 17, 2004

Reliability study of the Hemophilia Joint Health Score

The XXVI World Federation of Hemophillia Congress (October 17-21, 2004 - Bangkok, Thailand).
Authors
Hilliard P, Funk S, Zourikian N, Bergstrom B-M, Bradley CS, McLimont M, Manco-Johnson M, Petrini P, van den Berg M, and Feldman BM.
Citation
October 8, 2004

Physical therapy and imaging outcome measures in a haemophilia population treated with factor prophylaxis: current status and future directions.

Authors
Manco-Johnson MJ, Pettersson H, Petrini P, Babyn PS, Bergstrom B-M, Bradley CS , Doria AS, Feldman BM, Funk S, Hilliard P, Kilcoyne R, Lundin B, Nuss R, Rivard G, Schoenmakers MA, van den berg M, Wiedel J, Zourikian N, and Blanchette VS.
Citation
Haemophilia 2004 Oct; 10 (S4):88 – 93.
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